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Professor Gary F Egan

Gary Egan

Professor & Foundation Director, Monash Biomedical Imaging, Monash University
NHMRC Principal Research Fellow, School of Psychology & Psychiatry, Monash University
Deputy Director, National Imaging Facility, Australia
Churchill Fellow, Sir Winston Churchill Memorial Trust

BSc (Hons) University of Melbourne
MBA (1997) Monash University
PhD (1989) University of Melbourne

Tel: +61 3 9902 9750
Fax: +61 3 9902 9817
Email: gary.egan@monash.edu

Affiliations and memberships

  • Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM)
  • Australian Radiation Protection Society (ARPS)
  • Institute of Electrical and Electronic Engineers (IEEE), USA
  • International Organisation for Human Brain Mapping (OHBM), USA
  • International Society for Magnetic Resonance in Medicine (ISMRM), USA
  • Australian Neuroscience Society
  • Society for Neuroscience, USA
  • Governing Board Member, International Neuroinformatics Co-ordinating Facility (INCF) Stockholm
  • Member, Board of Directors, Society for Brain Mapping and Therapeutics Australasia (SMBTA)
  • Member, International Neuroinformatics Co-ordinating Facility (INCF) Training Committee
  • Member, NHMRC Research Translation Faculty
  • Member, NHMRC Assigners Academy
  • Chairperson, Imaging and Visualisation Scientific Advisory Committee (IVSAC), Multi-modal Australian Sciences Imaging and Visualisation Environment (MASSIVE) Computational Initiative, Melbourne
  • Member, Platforms Advisory Committee, National Neuroscience Facility, Melbourne
  • Chairperson, Neuroinformatics Platform, National Neuroscience Facility, Melbourne
  • Member & Ambassador, Club Melbourne, State Government of Victoria
  • Member, Advisory Board, Centre for Computational Science, Faculty of Information Technology, Monash University.
  • Theme Leader, Life Sciences Computation Centre (LSCC), Victorian Life Sciences Computational Initiative, Melbourne
  • Member, Executive, Florey Neuroscience Institutes
  • Member, Academic Board, University of Melbourne
  • Member, Victorian Steering Committee of the UK/Victoria Cooperative Research Agenda
  • Member, Executive Group, MRI Research Facility, Murdoch Children's Research Institute
  • Member, Bio21 Scientific Advisory Council Clinico-Bioinformatics Working Group, University of Melbourne
  • Member, eResearch Working Group, University of Melbourne
  • Member, Research Infrastructure & Strategic Research Planning Committees, Howard Florey Institute
  • Member, Neuroimaging Platform, NeuroSciences Victoria (NSV), Melbourne
  • Neuroimaging Group Leader, Howard Florey Institute, Melbourne
  • Associate Editor, Human Brain Mapping, Wiley Publishers, San Diego
  • Member, Editorial Board, International Journal of Imaging Systems and Technology, Wiley, USA
  • Member, Editorial Board, Neuroimage, Elsevier Publishers, USA
  • Member, Editorial Board, Frontiers in Neuroscience, Frontiers Research Foundation, Switzerland
  • Member, Editorial Board, BrainMap Database, Research Imaging Centre, San Antonio, Texas, USA & Wiley Publishers, San Diego

Research interests

  • Magnetic Resonance Imaging (structural, functional and connectivity)
  • Neuroinformatics
  • Biomedical Engineering

Biography

Gary Egan is an NHMRC Principal Research Fellow and the Professor and Director of Monash Biomedical Imaging, a research platform that encompasses the biomedical imaging research facilities currently being established at Monash University. He undertakes high resolution structural and functional brain mapping research and clinical neuroimaging research in Multiple Sclerosis and Huntington's disease. He is also the lead investigator of the Victorian Biomedical Imaging Capability and the Deputy Director of the Australian National Imaging Facility.

He has sustained success in obtaining significant and substantial grants to support his research, having received $19.89 million funding as a named CI on 27 peer reviewed grants in the past five years. He has been awarded 18 NHMRC grants, 14 ARC grants, 2 NIH grants and 31 other grants as a named chief investigator (CI) in competitive grant applications.

He has achieved of a substantive body of published work that is making a significant impact on the neuroimaging and neuroscience fields. He has published over 180 papers and over 300 abstracts in peer reviewed journals. He has an H-score of 35 and over 3600 citations (since 2008) to his publications. He has the ability to attract high-quality postgraduate students and postdoctoral fellows and he has supervised 34 postgraduate and post-doctoral students, with eight completing in the past 5 years. The citations for his work are available at Google Scholar Citations.

Recent publications

  1. H. Akhalghi, L. Corben, N. Georgiou-Karistianis, J. Bradshaw, E. Storey, M.B. Delatycki, G.F. Egan, “Superior cerebellar peduncle atrophy in Friedreich’s ataxia correlates with disease symptoms”, Cerebellum 11 (2011) 81-7. [IF 3.85]
  2. A. Zalesky, A. Fornito, M. Seal, L. Cochi, C-F. Westin, E.T. Bullmore, G.F. Egan, C. Pantelis, “Evidence of disruption to cortical fiber tract network in schizophrenia”, Biological Psychiatry 69 (2011) 80-9 [IF 9.8]
  3. A. Ng, L.A. Johnston, Z. Chen, Z-H. Cho, J. Zhang, G.F. Egan, “Spatially dependent filtering for removing phase distortions at the cortical surface”, Magnetic Resonance Medicine March 66 (2011) 784-93 [IF 3.3].
  4. L.J. Cole, M. Gavrilescu, L.A. Johnston, S.J. Gibson, M.J. Farrell, G.F. Egan, “ The impact of Alzheimer’s disease on the functional connectivity between brain regions underlying pain perception”, Eur. J Pain 15 (2011) 568.e1-e11.
  5. I. Bohanna, N. Georgiou-Karistianis, A. Sritharan, H. Asadi, L. Johnston, A. Churchyard, G.F. Egan, “Motor and cognitive deficits are associated with distinct patterns of white matter degeneration in Huntington’s disease”, Brain Imaging & Behaviour 5 (2011) 171-80.
  6. I. Bohanna, N. Georgiou-Karistianis, G.F. Egan, “Connectivity-based segmentation of the striatum in Huntington's disease: vulnerability of motor pathways”, Neurobiology of Diseases 42 (2011) 475-81.
  7. S.B. Mazzone, L.J. Cole, A. Ando, G.F. Egan, M.J. Farrell, “Identification of the neural control of cough and cough suppression in humans using functional brain imaging”, J Neuroscience 31 (2011) 2948-58.
  8. M.J. Farrell, J. Johnson, R. McAllen, F. Zamarripa, D.A. Denton, P.T. Fox, G.F. Egan, “Brain activation associated with ratings of the hedonic component of thermal sensation during whole body warming and cooling”, J. Thermal Biology 36 (2011) 57-63.
  9. S.C. Kolbe, C.E. Bajraszewski, C. Chapman, T. Nguyen, P. Mitchell, M. Paine, L.A. Johnston, H. Butzkueven, T.J. Kiltpatrick, G.F. Egan, “Diffusion tensor imaging of the optic radiations after optic neuritis”, Human Brain Mapping  doi 10.1002/hbm.21343 (2011).
  10. D.K. Thompson, T.E. Inder, N. Faggian, L. Johnston, S.K. Warfield, P.J. Anderson, L.W. Doyle, G.F. Egan, “Characterization of the corpus callosum in very preterm and full-term infants utilizing MRI”, Neuroimage 55 (2011) 479-90.
  11. L.A. Corben, H. Akhalghi, N. Karistianis-Georgiou, J.L.B. Bradshaw, G.F. Egan, E. Storey, A.J. Churchyard, M.B. Delatycki, “Impaired inhibition of prepotent motor tendencies in Friedreich ataxia demonstrated by the Simon interference task”, Brain and Cognition 76 (2011) 140-5.
  12. A. Zalesky, A. Fornito, G.F. Egan, C. Pantelis, E.T. Bullmore, “Relationship between regional and resting-state functional connectivity in schizophrenia”, accepted by Human Brain Mapping, May 2011 [IF 5.4]
  13. M. Stein, Y. Liu, O. Gray, J. Baker, S. Kolbe, M. Ditchfield, G.F. Egan, P. Mitchell, L. Harrison, H. Butzkueven, T. Kilpatrick, “A randomised trial of high-dose vitamin D2 in relapsing remitting multiple sclerosis”, Neurology 77 (2011) 1611-8. [IF 8.2]
  14. K. Richards, R. Buckley, N. Kurniawan, M. Keller, R. Beare, Charles Watson4,6 and the Australian Mouse Brain Mapping Consortium (P. Bartlett, G.F. Egan, G. Galloway, G. Paxinos, S. Petrou, D. Reutens), “Segmentation of the mouse hippocampal formation in magnetic resonance images”, Neuroimage 58 (2011) 732-40. [IF 5.4]
  15. M.J. Farrell, T.K. Bowala, M. Gavrilescu, P.A. Phillips, M. McKinley, D.A. Denton, G.F. Egan, “ Functional connectivity of the lamina terminalis during thirst in humans: a perfusion MRI study”, Amer. J Physiology 301 (2011) 623-31. [IF 7.7].
  16. S.L. Davison, R.J. Bell, M. Gavrilescu, K. Searle, P. Maruff, A. Gogos, S.L. Rossell, J. Adams, P. Robinson, G.F. Egan, S.R. Davis, “Testosterone Improves Verbal Learning and Memory in Postmenopausal Women: Results from a Pilot Study”, Maturitas 70 (2011) 307-11. [IF 2.3]
  17. L. Johnston, M. Gavrilescu, G.F. Egan, “A stochastic linear model for fMRI activation analyses”, Med Image Comput. Assist Interv. 14 (2011) 293-301 [IF 3.6]
  18. L.A. Johnston, I.M.Y. Mareels, G.F. Egan, “Bayesian model evidence for linear Gaussian models”, Conf. Proc IEEE Eng Med Biol Soc (2011) 5048-51.
  19. Davison SL, Bell RJ, Gavrilescu M, Searle K, Maruff P, Gogos A, Rossell SL, Adams J, Egan GF, Davis SR. Testosterone improves verbal learning and memory in postmenopausal women: Results from a pilot study. Maturitas 70 (2011) 307-11
  20. M.J. Farrell, L.J. Cole, D. Chiapoco, G.F. Egan, S.B. Mazzone, “Neural correlates coding stimulus intensity and perception of capsaicin urge-to-cough”, Neuroimage 61 (2012) 1324-35.
  21. P. Lei, S. Ayton, D.I. Finkelstein, L. Spoerri, G.D. Ciccotosto, D.K. Wright, B.X.W. Wong, P.A. Adlard, R.A. Cherny, L.Q. Lam, B.R. Roberts, I. Volitakis, G.F. Egan, C. McLean, R. Cappai, J.A. Duce, A.I. Bush, “Tau deficiency induces a Parkinsonism with dementia phenotype by obtunding APP-mediated iron export and is prevented by clioquinol”, Nature Medicine 18 (2012) 291-5 [IF 25.4]
  22. B.W. Muir, D. Acharya, D. Kennedy, X. Mulet, R. Evans, S. Pereira, K. Wark, T. Hinton, L. Waddington, N. Kirby, D. Wright, H. Wang, G.F Egan, B.A. Moffat, “Metal free T1 enhancing MRI contrast agents using lyotropic liquid crystal nanoparticles”, Biomaterials 33 (2012) 2723-33 [IF 9.1]
  23. D.K. Thompson, S.J. Wood, T.E. Inder, S.K. Warfield, L.W. Doyle, G.F. Egan, “Optimizing hippocampal volumetry in newborn infants utilizing MRI post-acquisition processing”, Neuroinformatics 10 (2012) 173-80 [IF 3.0]
  24. S.C. Kolbe, M. Marriott, A. van der Walt, J. Fielding, A. Klistorner, P.J. Mitchell, H. Butzkueven, T.J. Kilpatrick, G.F. Egan, “Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis”, Investigative Ophthalmology & Visual Science (IOVS) 53 (2012) 825-32.
  25. C. Davey, D.B. Grayden, M. Gavrilescu, G.F. Egan, L.A. Johnston, “The equivalence of linear Gaussian connectivity techniques”, accepted Human Brain Mapping, (January, 2012) doi: 10.1002/hbm.22043 [IF 5.4]
  26. C. Murawski, P.G. Harris, S. Bode, J.F. Dominguez D, G.F. Egan, “Led into temptation? Subliminally presented reward cues bias incidental economic decisions”, PLoS One 7 (2012) e34155.
  27. N. Georgiou-Karistianis, H. Akhlaghi, L. Corben, M. Delatycki, E. Storey, J. L. Bradshaw, G. F. Egan, “Decreased functional brain activation in Friedreich’s ataxia using the Simon effect task”, Brain & Cognition 79 (2012) 200-8.
  28. D.K. Thompson, T.E. Inder, N. Faggian, S.K. Warfield, P.J. Anderson, L.W. Doyle, G.F. Egan, “Corpus callosum alterations in very preterm infants: perinatal correlates and 2 year neurodevelopmental outcomes”, Neuroimage. 59 (2012) 3571-81.
  29. D. Acharya, B.A. Moffat, A. Polyzos, L. Waddington, G. Coia, D. Wright, H. Wang, G.F. Egan, B.W. Muir, P. Hartley, “Cubic Mesophase Nanoparticles doped with Superparamagnetic Iron Oxide Nanoparticles; a new class of MRI contrast agent”, accepted in Royal Society Chemistry Advances (May, 2012).
  30. J.P. Ullmann, M.D. Keller, C. Watson, A. Janke, N.D. Kurniawan, Z. Yang, K. Richards, G. Paxinos, G.F. Egan, S. Petrou, P.F. Bartlett, G.J. Galloway, D.C. Reutens, “Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images”, Neuroimage (2012).
  31. N. Georgiou-Karistianis, J. Stout, S.P. Carron, A.R Dymowski, A. Ando, A. Churchyard, P. Chua, I. Bohanna, G.F. Egan, “An fMRI investigation of the neural correlates of spatial working memory in pre-diagnosis and early symptomatic Huntington’s disease: IMAGE-HD cross-sectional analysis”, accepted Human Brain Mapping (May, 2012).
  32. Y. Liu, P.J. Mitchell, T.J. Kilpatrick, M.S. Stein, L.C. Harrison, J. Baker, M. Ditchfield, K. Li, G.F. Egan, H. Butzkueven, S.C. Kolbe, “Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis”, accepted in J. Clinical Neuroscience (2012) Dec;19(12):1689-94
  33. N. Georgiou-Karistianis, M.A. Gray, D.J. Dominguez, A.R. Dymowski, I. Bohanna, L.A. Johnston, A. Churchyard, P. Chua, J.C. Stout, G.F. Egan, “Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: The IMAGE-HD study”, Neurobiology of Diseases (2012) 2012 Oct 13.
  34. H. Akhalghi, L. Corben, N. Georgiou-Karistianis, J. Bradshaw, M.B. Delatycki, E. Storey, G.F. Egan, “A functional MRI study of motor dysfunction in Friedreich’s ataxia”, Brain Research 1471 (2012) 138-154 [IF 8.8]
  35. J.R. Duncan, A.L. Dick, G.F. Egan, S. Kolbe, M. Gavrilescu, D. Wright, A.J. Lawrence, “Adolescent toluene inhalation in rats affects white matter maturation with the potential for recovery following abstinence”, PLoS One accepted (August, 2012).
  36. M.M. Gresle, E.N. Alexandrou, Q. Wu, G.F. Egan, V. Jokubaitis, M.M Ayers, A. Jonas, W. Doherty, A.Friedhuber, G. Shaw, M. Sendtner, B.Emery, T.J Kilpatrick, H. Butzkueven, “Leukemia inhibitory factor protects axons in experimental autoimmune encephalomyelitis via an oligodendrocyte-independent mechanism”, PLoS ONE accepted (September, 2012).
  37. Y. Wang, A. van der Walt, M. Paine, A. Klistorner, H. Butzkueven, G.F. Egan, T.J. Kilpatrick, S.C. Kolbe, “Optic nerve magnetization transfer ratio after acute optic neuritis predicts axonal and visual outcomes”, accepted in PLoS One (Nov, 2012).
  38. M.A. Gray, G.F. Egan, A. Ando, A. Churchyard, P. Chua, J.C. Stout, N. Georgiou-Karistianis, “Prefrontal activity in Huntington’s disease reflects cognitive and neuropsychiatric disturbances: The IMAGE-HD study”, Exp. Neurology 239 (2012) 218-228.
  39. S. Dedeurwaerdere, K. Fang, M. Chow, Y. Shen, I. Noordman, L.Van Raay, N. Faggian, M. Porritt, G.F. Egan, T.J. O'Brien, “Manganese-Enhanced MRI reflects seizure outcome in a model for mesial temporal lobe epilepsy”, revision submitted to Neuroimage (Oct, 2012).
  40. S.C. Kolbe, L. Millist, P.J. Mitchell, T.J. Kilpatrick, O. White, G.F. Egan, J. Fielding, “Dysfunctional inhibitory eye movements are associated with cerebellar injury in multiple sclerosis”, accepted by Human Brain Mapping (November, 2012) subject to revisions
  41. C.E. Davey, D.B. Grayden, G.F. Egan, L.A. Johnston, “Filtering induces correlation in fMRI resting state data”, Neuroimage (2013) 64:728-40.
  42. S.L. Davison, R.J. Bell, P. Robinson, F. Jane, J. Leech, P. Maruff, G.F. Egan, S.R. Davis, “Continuous combined oral estradiol plus drospirenone has neutral effects on cognitive performance and improves estrogen deficiency symptoms in early postmenopausal women; a randomized placebo controlled trial”, accepted by Menopause (January, 2013) 

Current research grants

  1. NHMRC Project #1009757: ‘Assessing paraclinical measures of axonal degeneration following acute optic neuritis’ (2011-13) Chief Investigators: G.F. Egan, A. Klistorner, H. Butzkueven
  2. NHMRC Principal Research Fellowship Grant #1003993: “Development of ultrahigh resolution brain imaging for investigating neurological and neurodegenerative diseases”, G.F. Egan (2011-15)
  3. NHMRC Project Grant APP1042528, ‘Activity in central cough networks in patients with cough hypersensitivity’ (2013-2015) Chief Investigators: S. Mazzone, M. Farrell, G.F. Egan
  4. NHMRC Project Grant APP1046037: ‘A longitudinal neuroimaging study investigating reorganisation of cerebellar-cerebral networks in Friedreich ataxia’, (2013-2016) Chief Investigators: N Georgiou-Karistianis, G.F. Egan, M. Delatycki, A. Churchyard, L. Corben
  5. NHMRC Project APP1042893: ‘A role for the pulvinar nucleus in visual cortical development and plasticity’ (2013-15) Chief Investigators: J. Bourne, D. Leopold, G.F. Egan
  6. ARC Discovery Project DP110102084: “The cognitive control of saccades: Identifying neuroanatomical and neurophysiological substrates”, (2011-13) Chief Investigators: J. Fielding, G.F. Egan
  7. ARC Linkage Project LP110100470: “An integrative and distributed data management and workflow framework for e-research in biomedical imaging”, (2011-13) Chief Investigators: G.F. Egan, S. Milton, J. Lohrey, A. Lonie, D. Abramson
  8. ARC LE130100035: “Hyperpolarised gas functional lung and molecular imaging”, (2013) F.C. Thien, B.R. Thompson, G.F. Egan, S.B. Hooper, W-T. Lee, P.J. Robinson, G.J. Galloway, G.J. Cowin, I.M. Brereton
  9. National Collaborative Research Infrastructure Scheme (NCRIS), Characterisation Capability: “National Imaging Facility”, (2007-12) Co-Principal Investigators – G. Galloway (Director), G.F. Egan (Deputy Director), Co-Investigators – I. Brereton, R. Banati, C. Rae, D. Reutens, A. Connelly, H. Morris, R. Vink
  10. Education Investment Fund (EIF3) “Expanded National Imaging Facility”, (2011-13) Co-Principal Investigators – D. Reutens, G. Galloway, G.F. Egan, I. Brereton, C. Rae, I. Smith, M. Kyrios              
  11. Collaborative Research Infrastructure Scheme (CRIS) “Support for the National Imaging Facility”, (2013-14) Co-Principal Investigators –G. Galloway, D. Reutens, G.F. Egan, I. Brereton, C. Rae, M. Kyrios (TOTAL   $ 4,287,450)
  12. Cure Huntington’s Disease Initiative Foundation Inc. (CHDI) (USA). Investigators: N. Georgiou-Karistianis, G.F. Egan, J. Stout, A. Hannan, E. Chiu, & A. Churchyard. “A neuroimaging study investigating brain structure, function, and connectivity in pre-diagnosis and early symptomatic Huntington’s disease individuals using fMRI and DTI (IMAGE-HD)”. (2010-13)